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Compiles Metadata from PKNCA

Usage

NCA_fetch_PKNCA_meta()

Value

Dataframe containing PKCNA metadata for NCA parameters.

Examples

PKNCA_meta = NCA_fetch_PKNCA_meta()
utils::head(PKNCA_meta)
#> $parameters
#>                 parameter                unit_type
#> 1                   start                     time
#> 2                     end                     time
#> 3                 auclast                      auc
#> 4                  aucall                      auc
#> 5                aumclast                     aumc
#> 6                 aumcall                     aumc
#> 7             aucint.last                      auc
#> 8        aucint.last.dose                      auc
#> 9              aucint.all                      auc
#> 10        aucint.all.dose                      auc
#> 11           aumcint.last                     aumc
#> 12      aumcint.last.dose                     aumc
#> 13            aumcint.all                     aumc
#> 14       aumcint.all.dose                     aumc
#> 15                     c0                     conc
#> 16                   cmax                     conc
#> 17                   cmin                     conc
#> 18                   tmax                     time
#> 19                  tlast                     time
#> 20                 tfirst                     time
#> 21              clast.obs                     conc
#> 22                cl.last                clearance
#> 23                 cl.all                clearance
#> 24             cl.int.all                clearance
#> 25            cl.int.last                clearance
#> 26                      f                 fraction
#> 27               mrt.last                     time
#> 28                mrt.all                     time
#> 29            mrt.int.all                     time
#> 30           mrt.int.last                     time
#> 31            mrt.iv.last                     time
#> 32               vss.last                   volume
#> 33            vss.iv.last                   volume
#> 34                vss.all                   volume
#> 35            vss.int.all                   volume
#> 36           vss.int.last                   volume
#> 37                    cav                     conc
#> 38           cav.int.last                     conc
#> 39            cav.int.all                     conc
#> 40                ctrough                     conc
#> 41                 cstart                     conc
#> 42                    ptr                 fraction
#> 43                   tlag                     time
#> 44               deg.fluc                        %
#> 45                  swing                        %
#> 46                   ceoi                     conc
#> 47   aucabove.predose.all                      auc
#> 48    aucabove.trough.all                      auc
#> 49             count_conc                    count
#> 50    count_conc_measured                    count
#> 51                totdose                     dose
#> 52                  volpk                   volume
#> 53                     ae                   amount
#> 54               clr.last          renal_clearance
#> 55                     fe              amount_dose
#> 56                 ertlst                     time
#> 57                  ermax              amount_time
#> 58                 ertmax                     time
#> 59         sparse_auclast                      auc
#> 60          sparse_auc_se                      auc
#> 61          sparse_auc_df                    count
#> 62        sparse_aumclast                     aumc
#> 63         sparse_aumc_se                     aumc
#> 64         sparse_aumc_df                    count
#> 65             time_above                     time
#> 66              aucivlast                      auc
#> 67               aucivall                      auc
#> 68          aucivint.last                      auc
#> 69           aucivint.all                      auc
#> 70         aucivpbextlast                        %
#> 71          aucivpbextall                        %
#> 72     aucivpbextint.last                        %
#> 73      aucivpbextint.all                        %
#> 74             aumcivlast                     aumc
#> 75              aumcivall                     aumc
#> 76         aumcivint.last                     aumc
#> 77          aumcivint.all                     aumc
#> 78              half.life                     time
#> 79              r.squared                 unitless
#> 80          adj.r.squared                 unitless
#> 81        lambda.z.corrxy                 unitless
#> 82               lambda.z             inverse_time
#> 83    lambda.z.time.first                     time
#> 84     lambda.z.time.last                     time
#> 85      lambda.z.n.points                    count
#> 86             clast.pred                     conc
#> 87             span.ratio                 fraction
#> 88         thalf.eff.last                     time
#> 89      thalf.eff.iv.last                     time
#> 90               kel.last             inverse_time
#> 91            kel.iv.last             inverse_time
#> 92                kel.all             inverse_time
#> 93            kel.int.all             inverse_time
#> 94           kel.int.last             inverse_time
#> 95              cl.iv.all                clearance
#> 96             cl.iv.last                clearance
#> 97           cl.ivint.all                clearance
#> 98          cl.ivint.last                clearance
#> 99         cl.sparse.last                clearance
#> 100       mrt.sparse.last                     time
#> 101            mrt.iv.all                     time
#> 102         mrt.ivint.all                     time
#> 103        mrt.ivint.last                     time
#> 104                vz.all                   volume
#> 105            vz.int.all                   volume
#> 106           vz.int.last                   volume
#> 107             vz.iv.all                   volume
#> 108            vz.iv.last                   volume
#> 109          vz.ivint.all                   volume
#> 110         vz.ivint.last                   volume
#> 111               vz.last                   volume
#> 112        vz.sparse.last                   volume
#> 113            vss.iv.all                   volume
#> 114         vss.ivint.all                   volume
#> 115        vss.ivint.last                   volume
#> 116       vss.sparse.last                   volume
#> 117            aucinf.obs                      auc
#> 118           aucinf.pred                      auc
#> 119           aumcinf.obs                     aumc
#> 120          aumcinf.pred                     aumc
#> 121        aucint.inf.obs                      auc
#> 122   aucint.inf.obs.dose                      auc
#> 123       aucint.inf.pred                      auc
#> 124  aucint.inf.pred.dose                      auc
#> 125       aumcint.inf.obs                     aumc
#> 126  aumcint.inf.obs.dose                     aumc
#> 127      aumcint.inf.pred                     aumc
#> 128 aumcint.inf.pred.dose                     aumc
#> 129          aucivinf.obs                      auc
#> 130         aucivinf.pred                      auc
#> 131     aucivpbextinf.obs                        %
#> 132    aucivpbextinf.pred                        %
#> 133         aumcivinf.obs                     aumc
#> 134        aumcivinf.pred                     aumc
#> 135           aucpext.obs                        %
#> 136          aucpext.pred                        %
#> 137            kel.iv.all             inverse_time
#> 138         kel.ivint.all             inverse_time
#> 139        kel.ivint.last             inverse_time
#> 140       kel.sparse.last             inverse_time
#> 141                cl.obs                clearance
#> 142               cl.pred                clearance
#> 143        cl.int.inf.obs                clearance
#> 144       cl.int.inf.pred                clearance
#> 145             cl.iv.obs                clearance
#> 146            cl.iv.pred                clearance
#> 147               mrt.obs                     time
#> 148              mrt.pred                     time
#> 149       mrt.int.inf.obs                     time
#> 150      mrt.int.inf.pred                     time
#> 151            mrt.iv.obs                     time
#> 152           mrt.iv.pred                     time
#> 153            mrt.md.obs                     time
#> 154           mrt.md.pred                     time
#> 155                vz.obs                   volume
#> 156               vz.pred                   volume
#> 157        vz.int.inf.obs                   volume
#> 158       vz.int.inf.pred                   volume
#> 159             vz.iv.obs                   volume
#> 160            vz.iv.pred                   volume
#> 161               vss.obs                   volume
#> 162              vss.pred                   volume
#> 163            vss.iv.obs                   volume
#> 164           vss.iv.pred                   volume
#> 165            vss.md.obs                   volume
#> 166           vss.md.pred                   volume
#> 167       vss.int.inf.obs                   volume
#> 168      vss.int.inf.pred                   volume
#> 169       cav.int.inf.obs                     conc
#> 170      cav.int.inf.pred                     conc
#> 171               clr.obs          renal_clearance
#> 172              clr.pred          renal_clearance
#> 173         thalf.eff.obs                     time
#> 174        thalf.eff.pred                     time
#> 175      thalf.eff.iv.obs                     time
#> 176     thalf.eff.iv.pred                     time
#> 177               kel.obs             inverse_time
#> 178              kel.pred             inverse_time
#> 179            kel.iv.obs             inverse_time
#> 180           kel.iv.pred             inverse_time
#> 181       kel.int.inf.obs             inverse_time
#> 182      kel.int.inf.pred             inverse_time
#> 183            auclast.dn             auc_dosenorm
#> 184             aucall.dn             auc_dosenorm
#> 185         aucinf.obs.dn             auc_dosenorm
#> 186        aucinf.pred.dn             auc_dosenorm
#> 187           aumclast.dn            aumc_dosenorm
#> 188            aumcall.dn            aumc_dosenorm
#> 189        aumcinf.obs.dn            aumc_dosenorm
#> 190       aumcinf.pred.dn            aumc_dosenorm
#> 191               cmax.dn            conc_dosenorm
#> 192               cmin.dn            conc_dosenorm
#> 193          clast.obs.dn            conc_dosenorm
#> 194         clast.pred.dn            conc_dosenorm
#> 195                cav.dn            conc_dosenorm
#> 196            ctrough.dn            conc_dosenorm
#> 197           clr.last.dn renal_clearance_dosenorm
#> 198            clr.obs.dn renal_clearance_dosenorm
#> 199           clr.pred.dn renal_clearance_dosenorm
#>                                                   pretty_name data_type
#> 1                                              Interval Start  interval
#> 2                                                Interval End  interval
#> 3                                                     AUClast  interval
#> 4                                                      AUCall  interval
#> 5                                                   AUMC,last  interval
#> 6                                                    AUMC,all  interval
#> 7                     AUCint (based on AUClast extrapolation)  interval
#> 8         AUCint (based on AUClast extrapolation, dose-aware)  interval
#> 9                      AUCint (based on AUCall extrapolation)  interval
#> 10         AUCint (based on AUCall extrapolation, dose-aware)  interval
#> 11                  AUMCint (based on AUMClast extrapolation)  interval
#> 12      AUMCint (based on AUMClast extrapolation, dose-aware)  interval
#> 13                   AUMCint (based on AUMCall extrapolation)  interval
#> 14       AUMCint (based on AUMCall extrapolation, dose-aware)  interval
#> 15                                                         C0  interval
#> 16                                                       Cmax  interval
#> 17                                                       Cmin  interval
#> 18                                                       Tmax  interval
#> 19                                                      Tlast  interval
#> 20                                                     Tfirst  interval
#> 21                                                      Clast  interval
#> 22                                      CL (based on AUClast)  interval
#> 23                                       CL (based on AUCall)  interval
#> 24                                   CL (based on AUCint.all)  interval
#> 25                                  CL (based on AUCint.last)  interval
#> 26                                            Bioavailability  interval
#> 27                                     MRT (based on AUClast)  interval
#> 28                                      MRT (based on AUCall)  interval
#> 29                                  MRT (based on AUCint.all)  interval
#> 30                                 MRT (based on AUCint.last)  interval
#> 31                      MRT (for IV dosing, based on AUClast)  interval
#> 32                                     Vss (based on AUClast)  interval
#> 33                      Vss (for IV dosing, based on AUClast)  interval
#> 34                                      Vss (based on AUCall)  interval
#> 35                                  Vss (based on AUCint.all)  interval
#> 36                                 Vss (based on AUCint.last)  interval
#> 37                                                        Cav  interval
#> 38                                                        Cav  interval
#> 39                                                        Cav  interval
#> 40                                                    Ctrough  interval
#> 41                                                     Cstart  interval
#> 42                                       Peak-to-trough ratio  interval
#> 43                                                       Tlag  interval
#> 44                                      Degree of fluctuation  interval
#> 45                                                      Swing  interval
#> 46                                                       Ceoi  interval
#> 47                                                  AUC,above  interval
#> 48                                                  AUC,above  interval
#> 49                                        Concentration count  interval
#> 50                               Measured concentration count  interval
#> 51                                                 Total dose  interval
#> 52                                         Total Urine Volume  interval
#> 53                                            Amount excreted  interval
#> 54                             Renal clearance (from AUClast)  interval
#> 55                                          Fraction excreted  interval
#> 56                                       Tlast excretion rate  interval
#> 57                                     Maximum excretion rate  interval
#> 58                                        Tmax excretion rate  interval
#> 59                                             Sparse AUClast  interval
#> 60                              Sparse AUClast standard error  interval
#> 61                          Sparse AUClast degrees of freedom  interval
#> 62                                            Sparse AUMClast  interval
#> 63                                 Sparse AUMC standard error  interval
#> 64                             Sparse AUMC degrees of freedom  interval
#> 65                                   Time above Concentration  interval
#> 66                                        AUClast (IV dosing)  interval
#> 67                                         AUCall (IV dosing)  interval
#> 68                                    AUCint,last (IV dosing)  interval
#> 69                                     AUCint,all (IV dosing)  interval
#> 70                                 AUCbext (based on AUClast)  interval
#> 71                                  AUCbext (based on AUCall)  interval
#> 72                             AUCbext (based on AUCint,last)  interval
#> 73                              AUCbext (based on AUCint,all)  interval
#> 74                                       AUMClast (IV dosing)  interval
#> 75                                        AUMCall (IV dosing)  interval
#> 76                                   AUMCint,last (IV dosing)  interval
#> 77                                    AUMCint,all (IV dosing)  interval
#> 78                                                  Half-life  interval
#> 79                                                      $r^2$  interval
#> 80                                                $r^2_{adj}$  interval
#> 81                               Correlation (time, log-conc)  interval
#> 82                                               $\\lambda_z$  interval
#> 83                                First time for $\\lambda_z$  interval
#> 84                                 Last time for $\\lambda_z$  interval
#> 85                         Number of points used for lambda_z  interval
#> 86                                                 Clast,pred  interval
#> 87                                                 Span ratio  interval
#> 88                    Effective half-life (based on MRT,last)  interval
#> 89      Effective half-life (for IV dosing, based on MRTlast)  interval
#> 90                                     Kel (based on AUClast)  interval
#> 91                      Kel (for IV dosing, based on AUClast)  interval
#> 92                                      Kel (based on AUCall)  interval
#> 93                                  Kel (based on AUCint.all)  interval
#> 94                                 Kel (based on AUCint.last)  interval
#> 95                       CL (for IV dosing,  based on AUCall)  interval
#> 96                      CL (for IV dosing,  based on AUClast)  interval
#> 97                 CL (IV dose interval, based on AUCint.all)  interval
#> 98                CL (IV dose interval, based on AUCint.last)  interval
#> 99                     CL (for sparse data, based on AUClast)  interval
#> 100                   MRT (for sparse data, based on AUClast)  interval
#> 101                      MRT (for IV dosing, based on AUCall)  interval
#> 102               MRT (IV dose interval, based on AUCint.all)  interval
#> 103              MRT (IV dose interval, based on AUCint.last)  interval
#> 104                                      Vz (based on AUCall)  interval
#> 105                                  Vz (based on AUCint.all)  interval
#> 106                                 Vz (based on AUCint.last)  interval
#> 107                      Vz (for IV dosing,  based on AUCall)  interval
#> 108                     Vz (for IV dosing,  based on AUClast)  interval
#> 109                Vz (IV dose interval, based on AUCint.all)  interval
#> 110               Vz (IV dose interval, based on AUCint.last)  interval
#> 111                                     Vz (based on AUClast)  interval
#> 112                    Vz (for sparse data, based on AUClast)  interval
#> 113                     Vss (for IV dosing,  based on AUCall)  interval
#> 114               Vss (IV dose interval, based on AUCint.all)  interval
#> 115              Vss (IV dose interval, based on AUCint.last)  interval
#> 116                   Vss (for sparse data, based on AUClast)  interval
#> 117                                                AUCinf,obs  interval
#> 118                                               AUCinf,pred  interval
#> 119                                              AUMC,inf,obs  interval
#> 120                                             AUMC,inf,pred  interval
#> 121                AUCint (based on AUCinf,obs extrapolation)  interval
#> 122    AUCint (based on AUCinf,obs extrapolation, dose-aware)  interval
#> 123               AUCint (based on AUCinf,pred extrapolation)  interval
#> 124   AUCint (based on AUCinf,pred extrapolation, dose-aware)  interval
#> 125              AUMCint (based on AUMCinf,obs extrapolation)  interval
#> 126  AUMCint (based on AUMCinf,obs extrapolation, dose-aware)  interval
#> 127             AUMCint (based on AUMCinf,pred extrapolation)  interval
#> 128 AUMCint (based on AUMCinf,pred extrapolation, dose-aware)  interval
#> 129                                    AUCinf,obs (IV dosing)  interval
#> 130                                   AUCinf,pred (IV dosing)  interval
#> 131                             AUCbext (based on AUCinf,obs)  interval
#> 132                            AUCbext (based on AUCinf,pred)  interval
#> 133                                   AUMCinf,obs (IV dosing)  interval
#> 134                                  AUMCinf,pred (IV dosing)  interval
#> 135                             AUCpext (based on AUCinf,obs)  interval
#> 136                            AUCpext (based on AUCinf,pred)  interval
#> 137                     Kel (for IV dosing,  based on AUCall)  interval
#> 138               Kel (IV dose interval, based on AUCint.all)  interval
#> 139              Kel (IV dose interval, based on AUCint.last)  interval
#> 140                   Kel (for sparse data, based on AUClast)  interval
#> 141                                  CL (based on AUCinf,obs)  interval
#> 142                                 CL (based on AUCinf,pred)  interval
#> 143                              CL (based on AUCint.inf.obs)  interval
#> 144                             CL (based on AUCint.inf.pred)  interval
#> 145                  CL (for IV dosing,  based on AUCinf,obs)  interval
#> 146                 CL (for IV dosing,  based on AUCinf,pred)  interval
#> 147                                 MRT (based on AUCinf,obs)  interval
#> 148                                MRT (based on AUCinf,pred)  interval
#> 149                             MRT (based on AUCint.inf.obs)  interval
#> 150                            MRT (based on AUCint.inf.pred)  interval
#> 151                  MRT (for IV dosing, based on AUCinf,obs)  interval
#> 152                 MRT (for IV dosing, based on AUCinf,pred)  interval
#> 153            MRT (for multiple dosing, based on AUCinf,obs)  interval
#> 154           MRT (for multiple dosing, based on AUCinf,pred)  interval
#> 155                                  Vz (based on AUCinf,obs)  interval
#> 156                                 Vz (based on AUCinf,pred)  interval
#> 157                              Vz (based on AUCint.inf.obs)  interval
#> 158                             Vz (based on AUCint.inf.pred)  interval
#> 159                  Vz (for IV dosing,  based on AUCinf,obs)  interval
#> 160                 Vz (for IV dosing,  based on AUCinf,pred)  interval
#> 161                                 Vss (based on AUCinf,obs)  interval
#> 162                                Vss (based on AUCinf,pred)  interval
#> 163                  Vss (for IV dosing, based on AUCinf,obs)  interval
#> 164                 Vss (for IV dosing, based on AUCinf,pred)  interval
#> 165               Vss (for multiple-dose, based on Clast,obs)  interval
#> 166              Vss (for multiple-dose, based on Clast,pred)  interval
#> 167                             Vss (based on AUCint.inf.obs)  interval
#> 168                            Vss (based on AUCint.inf.pred)  interval
#> 169                                                       Cav  interval
#> 170                                                       Cav  interval
#> 171                         Renal clearance (from AUCinf,obs)  interval
#> 172                        Renal clearance (from AUCinf,pred)  interval
#> 173                    Effective half-life (based on MRT,obs)  interval
#> 174                   Effective half-life (based on MRT,pred)  interval
#> 175     Effective half-life (for IV dosing, based on MRT,obs)  interval
#> 176    Effective half-life (for IV dosing, based on MRT,pred)  interval
#> 177                                 Kel (based on AUCinf,obs)  interval
#> 178                                Kel (based on AUCinf,pred)  interval
#> 179                  Kel (for IV dosing, based on AUCinf,obs)  interval
#> 180                 Kel (for IV dosing, based on AUCinf,pred)  interval
#> 181                             Kel (based on AUCint.inf.obs)  interval
#> 182                            Kel (based on AUCint.inf.pred)  interval
#> 183                                 AUClast (dose-normalized)  interval
#> 184                                  AUCall (dose-normalized)  interval
#> 185                              AUCinf,obs (dose-normalized)  interval
#> 186                             AUCinf,pred (dose-normalized)  interval
#> 187                               AUMC,last (dose-normalized)  interval
#> 188                                AUMC,all (dose-normalized)  interval
#> 189                            AUMC,inf,obs (dose-normalized)  interval
#> 190                           AUMC,inf,pred (dose-normalized)  interval
#> 191                                    Cmax (dose-normalized)  interval
#> 192                                    Cmin (dose-normalized)  interval
#> 193                                   Clast (dose-normalized)  interval
#> 194                              Clast,pred (dose-normalized)  interval
#> 195                                     Cav (dose-normalized)  interval
#> 196                                 Ctrough (dose-normalized)  interval
#> 197          Renal clearance (from AUClast) (dose-normalized)  interval
#> 198       Renal clearance (from AUCinf,obs) (dose-normalized)  interval
#> 199      Renal clearance (from AUCinf,pred) (dose-normalized)  interval
#>                                                                                                                                                                                                                                                                                                                                                              desc
#> 1                                                                                                                                                                                                                                                                                                                                   Starting time of the interval
#> 2                                                                                                                                                                                                                                                                                                              Ending time of the interval (potentially infinity)
#> 3                                                                                                                                                                                                                      The area under the concentration time curve from the beginning of the interval to the last concentration above the limit of quantification
#> 4                                                                                                     The area under the concentration time curve from the beginning of the interval to the last concentration above the limit of quantification plus the triangle from that last concentration to 0 at the first concentration below the limit of quantification
#> 5                                                                                                                                                                                                               The area under the concentration time moment curve from the beginning of the interval to the last concentration above the limit of quantification
#> 6                                                                                The area under the concentration time moment curve from the beginning of the interval to the last concentration above the limit of quantification plus the moment of the triangle from that last concentration to 0 at the first concentration below the limit of quantification
#> 7                                                                                                                                                                                                                                  The area under the concentration time curve in the interval extrapolating from Tlast to infinity with zeros (matching AUClast)
#> 8                                                                                                                                                                    The area under the concentration time curve in the interval extrapolating from Tlast to infinity with zeros (matching AUClast) with dose-aware interpolation/extrapolation of concentrations
#> 9                                                                                                                                                                           The area under the concentration time curve in the interval extrapolating from Tlast to infinity with the triangle from Tlast to the next point and zero thereafter (matching AUCall)
#> 10                                                                                                            The area under the concentration time curve in the interval extrapolating from Tlast to infinity with the triangle from Tlast to the next point and zero thereafter (matching AUCall) with dose-aware interpolation/extrapolation of concentrations
#> 11                                                                                                                                                                                                                                            The area under the moment curve in the interval extrapolating from Tlast to infinity with zeros (matching AUMClast)
#> 12                                                                                                                                                                              The area under the moment curve in the interval extrapolating from Tlast to infinity with zeros (matching AUMClast) with dose-aware interpolation/extrapolation of concentrations
#> 13                                                                                                                                                                                     The area under the moment curve in the interval extrapolating from Tlast to infinity with the triangle from Tlast to the next point and zero thereafter (matching AUMCall)
#> 14                                                                                                                       The area under the moment curve in the interval extrapolating from Tlast to infinity with the triangle from Tlast to the next point and zero thereafter (matching AUMCall) with dose-aware interpolation/extrapolation of concentrations
#> 15                                                                                                                                                                                                                                                                                                                        Initial concentration after an IV bolus
#> 16                                                                                                                                                                                                                                                                                                                                 Maximum observed concentration
#> 17                                                                                                                                                                                                                                                                                                                                 Minimum observed concentration
#> 18                                                                                                                                                                                                                                                                                                                     Time of the maximum observed concentration
#> 19                                                                                                                                                                                                                                                                                      Time of the last concentration observed above the limit of quantification
#> 20                                                                                                                                                                                                                                                                                              Time of the first concentration above the limit of quantification
#> 21                                                                                                                                                                                                                                                                                              The last concentration observed above the limit of quantification
#> 22                                                                                                                                                                                                                                                                                                       Clearance or observed oral clearance calculated to Clast
#> 23                                                                                                                                                                                                                                                                                                    Clearance or observed oral clearance calculated with AUCall
#> 24                                                                                                                                                                                                                                                                                                Clearance or observed oral clearance calculated with AUCint.all
#> 25                                                                                                                                                                                                                                                                                               Clearance or observed oral clearance calculated with AUCint.last
#> 26                                                                                                                                                                                                                                                                                                                    Bioavailability or relative bioavailability
#> 27                                                                                                                                                                                                                                                                                       The mean residence time to the last observed concentration above the LOQ
#> 28                                                                                                                                                                                                                                                                                                             Mean residence time calculated with AUCall/AUMCall
#> 29                                                                                                                                                                                                                                                                                       Mean residence time over interval calculated with AUCint.all/AUMCint.all
#> 30                                                                                                                                                                                                                                                                                     Mean residence time over interval calculated with AUCint.last/AUMCint.last
#> 31                                                                                                                                                                                                                                                        The mean residence time to the last observed concentration above the LOQ correcting for dosing duration
#> 32                                                                                                                                                                                                                                                                                              The steady-state volume of distribution calculating through Tlast
#> 33                                                                                                                                                                                                                                                                    The steady-state volume of distribution with intravenous infusion calculating through Tlast
#> 34                                                                                                                                                                                                                                                                                    Steady-state volume of distribution calculated with AUCall-based CL and MRT
#> 35                                                                                                                                                                                                                                                                                                  Steady-state volume of distribution using interval AUCint.all
#> 36                                                                                                                                                                                                                                                                                                 Steady-state volume of distribution using interval AUCint.last
#> 37                                                                                                                                                                                                                                                                                         The average concentration during an interval (calculated with AUClast)
#> 38                                                                                                                                                                                                                                                                                     The average concentration during an interval (calculated with AUCint.last)
#> 39                                                                                                                                                                                                                                                                                      The average concentration during an interval (calculated with AUCint.all)
#> 40                                                                                                                                                                                                                                                                                                                     The trough (end of interval) concentration
#> 41                                                                                                                                                                                                                                                                                                                                      The predose concentration
#> 42                                                                                                                                                                                                                                                                                                                                Peak-to-Trough ratio (fraction)
#> 43                                                                                                                                                                                                                                                                                                                                                       Lag time
#> 44                                                                                                                                                                                                                                                                                                                                          Degree of fluctuation
#> 45                                                                                                                                                                                                                                                                                                                                         Swing relative to Cmin
#> 46                                                                                                                                                                                                                                                                                                                           Concentration at the end of infusion
#> 47  The area under the concentration time the beginning of the interval to the last concentration above the limit of quantification plus the triangle from that last concentration to 0 at the first concentration below the limit of quantification, with a concentration subtracted from all concentrations and values below zero after subtraction set to zero
#> 48  The area under the concentration time the beginning of the interval to the last concentration above the limit of quantification plus the triangle from that last concentration to 0 at the first concentration below the limit of quantification, with a concentration subtracted from all concentrations and values below zero after subtraction set to zero
#> 49                                                                                                                                                                                                                                                                                                           Number of non-missing concentrations for an interval
#> 50                                                                                                                                                                                                                                                                                              Number of measured and non BLQ/ALQ concentrations for an interval
#> 51                                                                                                                                                                                                                                                                                                                     Total dose administered during an interval
#> 52                                                                                                                                                                                                                                                                                                                      The sum of urine volumes for the interval
#> 53                                                                                                                                                                                                                                                                                                            The amount excreted (typically into urine or feces)
#> 54                                                                                                                                                                                                                                                                                                                   The renal clearance calculated using AUClast
#> 55                                                                                                                                                                                                                                                                                                                              The fraction of the dose excreted
#> 56                                                                                                                                                                                                                                                               The midpoint collection time of the last measurable excretion rate (typically in urine or feces)
#> 57                                                                                                                                                                                                                                                                                                       The maximum excretion rate (typically in urine or feces)
#> 58                                                                                                                                                                                                                                                                       The midpoint collection time of the maximum excretion rate (typically in urine or feces)
#> 59                                                                                                                                                                                             For sparse PK sampling, the area under the concentration time curve from the beginning of the interval to the last concentration above the limit of quantification
#> 60                                                                                                                                                                       For sparse PK sampling, the standard error of the area under the concentration time curve from the beginning of the interval to the last concentration above the limit of quantification
#> 61                                                                                                                                                    For sparse PK sampling, the standard error degrees of freedom of the area under the concentration time curve from the beginning of the interval to the last concentration above the limit of quantification
#> 62                                                                                                                                                                                                         For sparse PK sampling, the area under the moment curve from the beginning of the interval to the last concentration above the limit of quantification
#> 63                                                                                                                                                                                                                                                                                  For sparse PK sampling, the standard error of the area under the moment curve
#> 64                                                                                                                                                                                                                                                                                  For sparse PK sampling, the degrees of freedom for the AUMC variance estimate
#> 65                                                                                                                                                                                                                                                                                                                               Time above a given concentration
#> 66                                                                                                                                                                                                                                                                    The AUClast calculated with back-extrapolation for intravenous dosing using extrapolated C0
#> 67                                                                                                                                                                                                                                                                     The AUCall calculated with back-extrapolation for intravenous dosing using extrapolated C0
#> 68                                                                                                                                                                                                                                                                The AUCint,last calculated with back-extrapolation for intravenous dosing using extrapolated C0
#> 69                                                                                                                                                                                                                                                                 The AUCint,all calculated with back-extrapolation for intravenous dosing using extrapolated C0
#> 70                                                                                                                                                                                                                                                                                         The back-extrapolation percent for intravenous dosing based on AUClast
#> 71                                                                                                                                                                                                                                                                                          The back-extrapolation percent for intravenous dosing based on AUCall
#> 72                                                                                                                                                                                                                                                                                     The back-extrapolation percent for intravenous dosing based on AUCint,last
#> 73                                                                                                                                                                                                                                                                                      The back-extrapolation percent for intravenous dosing based on AUCint,all
#> 74                                                                                                                                                                                                                                                                                           AUMClast with back-extrapolation using extrapolated C0 for IV dosing
#> 75                                                                                                                                                                                                                                                                                            AUMCall with back-extrapolation using extrapolated C0 for IV dosing
#> 76                                                                                                                                                                                                                                                               The AUMCint,last calculated with back-extrapolation for intravenous dosing using extrapolated C0
#> 77                                                                                                                                                                                                                                                                The AUMCint,all calculated with back-extrapolation for intravenous dosing using extrapolated C0
#> 78                                                                                                                                                                                                                                                                                                                                       The (terminal) half-life
#> 79                                                                                                                                                                                                                                                                                                                     The r^2 value of the half-life calculation
#> 80                                                                                                                                                                                                                                                                                                            The adjusted r^2 value of the half-life calculation
#> 81                                                                                                                                                                                                                                                                                             Correlation between time and log-concentration for lambda.z points
#> 82                                                                                                                                                                                                                                                                                                                 The elimination rate of the terminal half-life
#> 83                                                                                                                                                                                                                                                                                                     The first time point used for the calculation of half-life
#> 84                                                                                                                                                                                                                                                                                                      The last time point used for the calculation of half-life
#> 85                                                                                                                                                                                                                                                                                                     The number of points used for the calculation of half-life
#> 86                                                                                                                                                                                                                                                                                                       The concentration at Tlast as predicted by the half-life
#> 87                                                                                                                                                                                                                                                                                      The ratio of the half-life to the duration used for half-life calculation
#> 88                                                                                                                                                                                                                                                                                                       The effective half-life (as determined from the MRTlast)
#> 89                                                                                                                                                                                                                                                                                           The effective half-life (as determined from the intravenous MRTlast)
#> 90                                                                                                                                                                                                                                                                                                    Elimination rate (as calculated from the MRT using AUClast)
#> 91                                                                                                                                                                                                                                                                                                  Elimination rate (as calculated from the intravenous MRTlast)
#> 92                                                                                                                                                                                                                                                                                                               Elimination rate (as calculated from the MRTall)
#> 93                                                                                                                                                                                                                                                                                                           Elimination rate (as calculated from the MRTint.all)
#> 94                                                                                                                                                                                                                                                                                                          Elimination rate (as calculated from the MRTint.last)
#> 95                                                                                                                                                                                                                                                                                                        Clearance for intravenous dosing calculated with AUCall
#> 96                                                                                                                                                                                                                                                                                                       Clearance for intravenous dosing calculated with AUClast
#> 97                                                                                                                                                                                                                                                                                           Clearance for intravenous dosing calculated with interval AUCint.all
#> 98                                                                                                                                                                                                                                                                                          Clearance for intravenous dosing calculated with interval AUCint.last
#> 99                                                                                                                                                                                                                                                                                              Clearance from sparse sampling calculated with population AUClast
#> 100                                                                                                                                                                                                                                                                                                                      Mean residence time from sparse sampling
#> 101                                                                                                                                                                                                                                                                                              Mean residence time for IV dosing calculated with AUCall/AUMCall
#> 102                                                                                                                                                                                                                                                                                    Mean residence time for IV interval calculated with AUCint.all/AUMCint.all
#> 103                                                                                                                                                                                                                                                                                  Mean residence time for IV interval calculated with AUCint.last/AUMCint.last
#> 104                                                                                                                                                                                                                                                                                               Terminal volume of distribution calculated with AUCall-based CL
#> 105                                                                                                                                                                                                                                                                                                     Terminal volume of distribution using interval AUCint.all
#> 106                                                                                                                                                                                                                                                                                                    Terminal volume of distribution using interval AUCint.last
#> 107                                                                                                                                                                                                                                                                                                    Terminal volume of distribution for IV dosing using AUCall
#> 108                                                                                                                                                                                                                                                                                                   Terminal volume of distribution for IV dosing using AUClast
#> 109                                                                                                                                                                                                                                                                                              Terminal volume of distribution for IV interval using AUCint.all
#> 110                                                                                                                                                                                                                                                                                             Terminal volume of distribution for IV interval using AUCint.last
#> 111                                                                                                                                                                                                                                                                                              Terminal volume of distribution calculated with AUClast-based CL
#> 112                                                                                                                                                                                                                                                                                                          Terminal volume of distribution from sparse sampling
#> 113                                                                                                                                                                                                                                                                                                Steady-state volume of distribution for IV dosing using AUCall
#> 114                                                                                                                                                                                                                                                                                          Steady-state volume of distribution for IV interval using AUCint.all
#> 115                                                                                                                                                                                                                                                                                         Steady-state volume of distribution for IV interval using AUCint.last
#> 116                                                                                                                                                                                                                                                                                                      Steady-state volume of distribution from sparse sampling
#> 117                                                                                                                                                                                                             The area under the concentration time curve from the beginning of the interval to infinity with extrapolation to infinity from the observed Clast
#> 118                                                                                                                                                                                                            The area under the concentration time curve from the beginning of the interval to infinity with extrapolation to infinity from the predicted Clast
#> 119                                                                                                                                                                                                      The area under the concentration time moment curve from the beginning of the interval to infinity with extrapolation to infinity from the observed Clast
#> 120                                                                                                                                                                                                     The area under the concentration time moment curve from the beginning of the interval to infinity with extrapolation to infinity from the predicted Clast
#> 121                                                                                                                                                                                                                                The area under the concentration time curve in the interval extrapolating from Tlast to infinity with zeros (matching AUClast)
#> 122                                                                                                                                                                  The area under the concentration time curve in the interval extrapolating from Tlast to infinity with zeros (matching AUClast) with dose-aware interpolation/extrapolation of concentrations
#> 123                                                                                                                                                                         The area under the concentration time curve in the interval extrapolating from Tlast to infinity with the triangle from Tlast to the next point and zero thereafter (matching AUCall)
#> 124                                                                                                           The area under the concentration time curve in the interval extrapolating from Tlast to infinity with the triangle from Tlast to the next point and zero thereafter (matching AUCall) with dose-aware interpolation/extrapolation of concentrations
#> 125                                                                                                                                                                                                                                           The area under the moment curve in the interval extrapolating from Tlast to infinity with zeros (matching AUMClast)
#> 126                                                                                                                                                                             The area under the moment curve in the interval extrapolating from Tlast to infinity with zeros (matching AUMClast) with dose-aware interpolation/extrapolation of concentrations
#> 127                                                                                                                                                                                    The area under the moment curve in the interval extrapolating from Tlast to infinity with the triangle from Tlast to the next point and zero thereafter (matching AUMCall)
#> 128                                                                                                                      The area under the moment curve in the interval extrapolating from Tlast to infinity with the triangle from Tlast to the next point and zero thereafter (matching AUMCall) with dose-aware interpolation/extrapolation of concentrations
#> 129                                                                                                                                                                                                                                                                The AUCinf,obs calculated with back-extrapolation for intravenous dosing using extrapolated C0
#> 130                                                                                                                                                                                                                                                                          The  calculated with back-extrapolation for intravenous dosing using extrapolated C0
#> 131                                                                                                                                                                                                                                                                                     The back-extrapolation percent for intravenous dosing based on AUCinf,obs
#> 132                                                                                                                                                                                                                                                                                    The back-extrapolation percent for intravenous dosing based on AUCinf,pred
#> 133                                                                                                                                                                                                                                                                                                     AUMCinf,obs with back-extrapolation using extrapolated C0
#> 134                                                                                                                                                                                                                                                                                                    AUMCinf,pred with back-extrapolation using extrapolated C0
#> 135                                                                                                                                                                                                                                                                     Percent of the AUCinf that is extrapolated after Tlast calculated from the observed Clast
#> 136                                                                                                                                                                                                                                                                    Percent of the AUCinf that is extrapolated after Tlast calculated from the predicted Clast
#> 137                                                                                                                                                                                                                                                                                                          Elimination rate (as calculated from the MRTiv.all))
#> 138                                                                                                                                                                                                                                                                                                        Elimination rate (as calculated from the MRTivint.all)
#> 139                                                                                                                                                                                                                                                                                                       Elimination rate (as calculated from the MRTivint.last)
#> 140                                                                                                                                                                                                                                                                                                      Elimination rate (as calculated from the MRTsparse.last)
#> 141                                                                                                                                                                                                                                                                                           Clearance or observed oral clearance calculated with observed Clast
#> 142                                                                                                                                                                                                                                                                                          Clearance or observed oral clearance calculated with predicted Clast
#> 143                                                                                                                                                                                                                                                                                           Clearance or observed oral clearance calculated with AUCint.inf.obs
#> 144                                                                                                                                                                                                                                                                                          Clearance or observed oral clearance calculated with AUCint.inf.pred
#> 145                                                                                                                                                                                                                                                                                                   Clearance for intravenous dosing calculated with AUCinf,obs
#> 146                                                                                                                                                                                                                                                                                                  Clearance for intravenous dosing calculated with AUCinf,pred
#> 147                                                                                                                                                                                                                                                                                                      The mean residence time to infinity using observed Clast
#> 148                                                                                                                                                                                                                                                                                                     The mean residence time to infinity using predicted Clast
#> 149                                                                                                                                                                                                                                                                              Mean residence time over interval calculated with AUCint.inf.obs/AUMCint.inf.obs
#> 150                                                                                                                                                                                                                                                                            Mean residence time over interval calculated with AUCint.inf.pred/AUMCint.inf.pred
#> 151                                                                                                                                                                                                                                                                       The mean residence time to infinity using observed Clast correcting for dosing duration
#> 152                                                                                                                                                                                                                                                                      The mean residence time to infinity using predicted Clast correcting for dosing duration
#> 153                                                                                                                                                                                                                                                                      The mean residence time with multiple dosing and nonlinear kinetics using observed Clast
#> 154                                                                                                                                                                                                                                                                     The mean residence time with multiple dosing and nonlinear kinetics using predicted Clast
#> 155                                                                                                                                                                                                                                                                                                      The terminal volume of distribution using observed Clast
#> 156                                                                                                                                                                                                                                                                                                     The terminal volume of distribution using predicted Clast
#> 157                                                                                                                                                                                                                                                                                                 Terminal volume of distribution using interval AUCint.inf.obs
#> 158                                                                                                                                                                                                                                                                                                Terminal volume of distribution using interval AUCint.inf.pred
#> 159                                                                                                                                                                                                                                                                                           Terminal volume of distribution for IV dosing using observed AUCinf
#> 160                                                                                                                                                                                                                                                                                          Terminal volume of distribution for IV dosing using predicted AUCinf
#> 161                                                                                                                                                                                                                                                                                                  The steady-state volume of distribution using observed Clast
#> 162                                                                                                                                                                                                                                                                                                 The steady-state volume of distribution using predicted Clast
#> 163                                                                                                                                                                                                                                                                        The steady-state volume of distribution with intravenous infusion using observed Clast
#> 164                                                                                                                                                                                                                                                                       The steady-state volume of distribution with intravenous infusion using predicted Clast
#> 165                                                                                                                                                                                                                                                                 The steady-state volume of distribution for nonlinear multiple-dose data using observed Clast
#> 166                                                                                                                                                                                                                                                                The steady-state volume of distribution for nonlinear multiple-dose data using predicted Clast
#> 167                                                                                                                                                                                                                                                                                             Steady-state volume of distribution using interval AUCint.inf.obs
#> 168                                                                                                                                                                                                                                                                                            Steady-state volume of distribution using interval AUCint.inf.pred
#> 169                                                                                                                                                                                                                                                                                 The average concentration during an interval (calculated with AUCint.inf.obs)
#> 170                                                                                                                                                                                                                                                                                The average concentration during an interval (calculated with AUCint.inf.pred)
#> 171                                                                                                                                                                                                                                                                                                               The renal clearance calculated using AUCinf,obs
#> 172                                                                                                                                                                                                                                                                                                              The renal clearance calculated using AUCinf,pred
#> 173                                                                                                                                                                                                                                                                                                       The effective half-life (as determined from the MRTobs)
#> 174                                                                                                                                                                                                                                                                                                      The effective half-life (as determined from the MRTpred)
#> 175                                                                                                                                                                                                                                                                                           The effective half-life (as determined from the intravenous MRTobs)
#> 176                                                                                                                                                                                                                                                                                          The effective half-life (as determined from the intravenous MRTpred)
#> 177                                                                                                                                                                                                                                                                                             Elimination rate (as calculated from the MRT with observed Clast)
#> 178                                                                                                                                                                                                                                                                                            Elimination rate (as calculated from the MRT with predicted Clast)
#> 179                                                                                                                                                                                                                                                                                                  Elimination rate (as calculated from the intravenous MRTobs)
#> 180                                                                                                                                                                                                                                                                                                 Elimination rate (as calculated from the intravenous MRTpred)
#> 181                                                                                                                                                                                                                                                                                                      Elimination rate (as calculated from the MRTint.inf.obs)
#> 182                                                                                                                                                                                                                                                                                                     Elimination rate (as calculated from the MRTint.inf.pred)
#> 183                                                                                                                                                                                                                                                                                                                                       Dose normalized auclast
#> 184                                                                                                                                                                                                                                                                                                                                        Dose normalized aucall
#> 185                                                                                                                                                                                                                                                                                                                                    Dose normalized aucinf.obs
#> 186                                                                                                                                                                                                                                                                                                                                   Dose normalized aucinf.pred
#> 187                                                                                                                                                                                                                                                                                                                                      Dose normalized aumclast
#> 188                                                                                                                                                                                                                                                                                                                                       Dose normalized aumcall
#> 189                                                                                                                                                                                                                                                                                                                                   Dose normalized aumcinf.obs
#> 190                                                                                                                                                                                                                                                                                                                                  Dose normalized aumcinf.pred
#> 191                                                                                                                                                                                                                                                                                                                                          Dose normalized cmax
#> 192                                                                                                                                                                                                                                                                                                                                          Dose normalized cmin
#> 193                                                                                                                                                                                                                                                                                                                                     Dose normalized clast.obs
#> 194                                                                                                                                                                                                                                                                                                                                    Dose normalized clast.pred
#> 195                                                                                                                                                                                                                                                                                                                                           Dose normalized cav
#> 196                                                                                                                                                                                                                                                                                                                                       Dose normalized ctrough
#> 197                                                                                                                                                                                                                                                                                                                                      Dose normalized clr.last
#> 198                                                                                                                                                                                                                                                                                                                                       Dose normalized clr.obs
#> 199                                                                                                                                                                                                                                                                                                                                      Dose normalized clr.pred
#>